Washington, D.C. : Congress of the U.S., Office of Technology Assessment : For sale by the Supt. of Docs., U.S.G.P.O., 1985 viii, 158 p (A Technical memorandum / Congress of the United States, Office of Technology Assessment) Unique Identifier : AIDSLINE CAT/8708425
Toronto, Ont., Canada : Canadian Gay Archives, 1985 iii, 314 p (Canadian Gay Archives publication ; no. 10) Unique Identifier : AIDSLINE CAT/8708954
McLeod DW; Miller AV; Miller AV
Contains entries to literature published between Apr. 1983 to Sep. 1984. Includes pamphlets, brochures, books, journal articles, flyers, and some press releases. Arranged under three sections, i.e. Medical press, Mainstream press, and Gay press. General index.
Rockville, Md. : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Office of Scientific Information ; Washington, DC : For sale by the Supt. of Docs., U.S. G.P.O., 1986 printing v, 19 p (DHHS publication ; no. (ADM)85-1432) Unique Identifier : AIDSLINE CAT/8708574
The clinical and immunological picture of the acquired immunodeficiency syndrome was investigated in six male homosexuals. The aim of this study was to establish the incidence of opportunistic infections and/or malignancies in South African homosexual males, the nature and mechanisms of underlying cellular immunodefic
With increasing frequency, employers are considering mandatory screening for substance abuse and AIDS. These tests are focusing attention on an area of growing concern for hospitals--employees right to privacy in the workplace--and prompting trustees to define an institutional philosophy for their hospital.
Between April 1984 and December 1985, 50 patients diagnosed as AIDS were observed in our Clinic. Risk factors were homosexuality in 21 cases (42%), drug addiction in 20 (40%), homosexuality and drug addiction in 3 (6%), haemophilia in 1 (2%). In the remaining 5 cases the infection was acquired by vertical transmission
Boll Ist Sieroter Milan. 1986;65(6):487-93. Unique Identifier : AIDSLINE MED/87213682
Borroni G; Panuccio A; Ballerini P; Gelosa L
We report serological screening of 1217 prisoners for HTLV III antibodies, HBV markers and lues tests. The prevalence for HTLV III Abs on the whole of prisoners controlled is 30.8%, among the drug-users is 60.7%, with a relative risk (RR) of 1.18 between males and females in this group. It is been observed a significa
Boll Ist Sieroter Milan. 1986;65(6):544-51. Unique Identifier : AIDSLINE MED/87213690
Robba L; Carissoni ML; Goglio A; Scudeller G
The authors monitored for 1 year 96 cases of ex-opiate addicts, belonging to two therapeutic Communities from Bergamo, a male and a female group, and a group of subjects living close to them (operators) or relatives and of laboratory technicians (51 cases on the whole). Protocols were set up with all the biochemical,
A clinically mild recurrent rash in a young male homosexual with acquired immune deficiency syndrome (AIDS)-related complex was found on histological examination to consist of a severe necrotizing folliculitis with underlying vasculitis. Follicular eruptions are amongst the seemingly banal dermatological disorders whi
Anticardiolipin antibody levels were determined in 73 homosexual men. Thirty of these patients had acquired immunodeficiency syndrome (AIDS), 16 patients had the AIDS-related complex (ARC) and 27 were healthy. Antibodies to human T-lymphotropic virus type III (HTLV-III) were detected in all patients with AIDS and ARC
Seven patients with acquired immunodeficiency syndrome (AIDS)/AIDS-related complex (ARC) and psoriasis are reported. The psoriasis first presented in close association with the AIDS/ARC. The cutaneous lesions were difficult to control with systemic antipsoriatic therapy when patients immune functions were depressed.
A case of a patient with the acquired immunodeficiency syndrome (AIDS) and acquired ichthyosis in conjunction with Kaposi s sarcoma is reported. The possibility of a connection between acquired ichthyosis and immune deficiency, particularly AIDS, is presented.
This clinical and biological study was undertaken to assess the prevalence of infection by HIV, HBV and HDV in male drug abusers entering a prison. One hundred and thirteen drug users accepted to be tested: 14 (12 p. 100) were homosexual; 12 (11 p. 100) consumed more than 80 g per day of alcohol. The mean duration of
Int J Addict. 1987 Mar;22(3):201-19. Unique Identifier : AIDSLINE MED/87221027
Friedman SR; Des Jarlais DC; Sotheran JL; Garber J; Cohen H; Smith D
Gays and intravenous (i.v.) drug users are the two largest risk groups for AIDS. Gays, unlike drug users, have formed many organizations to deal with AIDS. Data are presented indicating that gay individuals have more risk-reducing behavioral changes than have i.v. drug users. It is also shown that i.v. drug users are
Disseminated infection caused by Mycobacterium avium complex (MAC) is common in patients with acquired immune deficiency syndrome and is difficult to treat because of the high degree of resistance to antimycobacterial agents. Early diagnosis and treatment may prolong survival of patients with acquired immune deficienc
Cimolai N; Gill MJ; Jones A; Flores B; Stamm WE; Laurie W; Madden B; Shahrabadi MS
Campylobacter cinaedi was isolated from the blood of a 29-year-old homosexual man with previously diagnosed acquired immune deficiency syndrome. Subculturing of the organism was achieved with the use of 7% lysed horse blood and 10% sheep blood agars at 37 degrees C in a microaerophilic atmosphere. Problems associated
Fierer J; Wolf P; Seed L; Gay T; Noonan K; Haghighi P
Rhodococcus equi, formerly known as Corynebacterium equi, was isolated repeatedly from the blood of two patients with the acquired immune deficiency syndrome (AIDS). Neither of the patients had pneumonia while they were bacteraemic, whereas pneumonia has been present in all previously reported cases of human infection
A 65-year-old man with insulin-dependent diabetes developed intractable pruritus preceding weight loss and increasing fatiguability. Esophagogastroduodenoscopy revealed infection with Candida, cytomegalovirus , and Cryptosporidium. His T cell helper/suppressor ratio was inverted, an
Katz JD; Mitsuyasu R; Gottlieb MS; Lebow LT; Bonavida B
Our studies and other investigations have shown that NK effector cells can also mediate antibody-dependent cellular cytotoxicity (ADCC) through the use of the Fc gamma receptor on the NK cell membrane. Peripheral blood lymphocytes (PBL) derived from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-rela
The importance of Kaposi s Sarcoma, known for over a century, resides in its relation to AIDS. The localisation on the shaft of the penis is very rare even in the generalised forms, more so when the lesion is primary and localized. The basic lesion appears as a reddish-violet nodule. The authors report a case of a pri
Most people who are exposed to AIDS do not get the syndrome. It seems clear that there must be cofactors. Most people with AIDS have a history of alcohol or other drug use, and many of the drugs used have been shown to suppress the immune system. The correlation between drug use and development of AIDS in several popu
Since the initial reports of an immune deficiency syndrome affecting certain segments of the adult population (homosexual males, bisexual males, intravenous drug abusers, prostitutes, hemophiliacs, Haitian immigrants), a specific group of pediatric patients with an identical immunologic picture has been identified. Th
A case of Acquired Immunodeficiency Syndrome complicated by a severe myopathy is reported. All efforts aimed at documenting an infectious etiology for the myopathy were negative. The relationship of myopathy to AIDS is discussed.
N Engl J Med. 1987 Jun 18;316(25):1569-72. Unique Identifier : AIDSLINE MED/87228878
Johns DR; Tierney M; Felsenstein D
Within the past 18 months, we have seen four cases of neurosyphilis at our institution (two of meningovascular syphilis, one of acute syphilitic meningitis, and one of asymptomatic neurosyphilis) in young homosexual men with serologic evidence of exposure to human immunodeficiency virus (HIV). Two of the four patients
Nature. 1987 Jun 11-17;327(6122):473-6. Unique Identifier : AIDSLINE MED/87229054
Salk J
The long incubation period between infection and the development of clinical AIDS may be due to an immune response to the initial infection which persists with health and wanes with disease. If this response can be boosted, it may be possible to reduce the viral burden, prevent the development of disease and reduce co
A specter is haunting our streets--the specter of AIDS, a remorseless and incurable disease whose nature, transmission and effects still contain elements of mystery. The fear of AIDS is pervasive. Most of us experience this fear as an uneasy but usually abstract awareness of its presence in the society. This awareness
Report on a patient suffering from severe lung sarcoidosis and HTLV III-infection. Under combined treatment with cortisone and thymostimulin the patient recovered surprisingly well. The X-ray showed a frank improvement of the lung alterations, and in addition an extensive normalization of leucocytes and lymphocytes co
Alpha interferon has been the most widely studied biologic response modifier for the treatment of Kaposi s sarcoma (KS) associated with acquired immune deficiency syndrome (AIDS). At San Francisco General Hospital s AIDS Clinic, three sequential trials of recombinant interferon alfa-2b (Intron A) were conducted betwee
The rising number of cases of AIDS in Great Britain has important implications for all those who work in the health services. A group of pre-clinical students at the Royal Free Hospital School of Medicine, London, undertook a project in which they explored some of the sociological and epidemiological aspects of AIDS.
This case report describes the occurrence of a painful rectal ulcer and associated fecal incontinence in a male homosexual with acquired immune deficiency syndrome. At biopsy, the ulcer proved to be Kaposi s sarcoma. The unusual location and the atypical gross appearance of this lesion underscore the need for an aggre
Haubenstock A; Malamud SC; Pipala JH; Mernick MH; DeVries K; Base W; Zalusky R
Twelve patients with endemic Kaposi s sarcoma (KS) were entered into a clinical trial of vincristine (VCR) infusion. Patients received 5-day courses of VCR, 0.25 mg/m2/day by continuous infusion, after an 0.5 mg intravenous bolus injection. Courses were repeated every four weeks. Stabilization of disease occurred in n
The neuropathological findings in 13 patients with the acquired immune deficiency syndrome (AIDS) and with AIDS related complex (ARC) are reported. Six patients presented with neurological symptoms, whereas autopsy revealed CNS involvement in nine cases. Four patients showed neither neurological nor neuropathological
Am J Epidemiol. 1987 Jul;126(1):25-30. Unique Identifier : AIDSLINE MED/87238616
McGrady GA; Jason JM; Evatt BL
The time course of the epidemic of acquired immunodeficiency syndrome (AIDS) as it has occurred in the US hemophilia population is examined using surveillance data collected by the Centers for Disease Control (CDC). These data indicate that the epidemic course in hemophiliacs is distinguishable from that in the homose
Am J Psychiatry. 1987 Jun;144(6):742-7. Unique Identifier : AIDSLINE MED/87239017
Klein DE; Sullivan G; Wolcott DL; Landsverk J; Namir S; Fawzy FI
Two samples of homosexual men, 64 physicians and 58 university students, reported profound decreases in several sexual practices linked to transmission of acquired immune deficiency syndrome (AIDS). The physicians showed the greater reduction. When sociodemographic variables, health beliefs, feeling of control over ou
Am J Public Health. 1987 Jul;77(7):789-91. Unique Identifier : AIDSLINE MED/87239062
Kelly JA; St Lawrence JS; Smith S Jr; Hood HV; Cook DJ
A randomly selected sample of physicians in three large cities was asked to read one of four vignettes describing a patient. They then completed a set of objective attitude measures eliciting their reactions to the patient described in the vignette. The vignettes were identical except that the patient s illness was id
Am J Public Health. 1987 Jul;77(7):795-9. Unique Identifier : AIDSLINE MED/87239063
Lewis CE; Freeman HE; Corey CR
We conducted a telephone survey of a random sample of primary care physicians practicing throughout the State of California to determine their AIDS-related experiences and competencies. Interviews were completed early in 1986 with 1,000 family and general practitioners and internists, 60 per cent of those eligible. Da
Ann Emerg Med. 1987 Jul;16(7):802-4. Unique Identifier : AIDSLINE MED/87239580
Giberson TP; Kalyan-Raman K
Cryptococcal meningitis is an infrequent primary presentation of acquired immunodeficiency syndrome (AIDS). We report the case of a 33-year-old man with previously undiagnosed AIDS who presented with gait disturbance, acute blindness, and rapidly fatal neurologic det
Central nervous system toxoplasmosis was diagnosed in 12 immunosuppressed patients, eleven of whom had AIDS. Fever (9/12), confusion (7/12) and focal neurological manifestations (6/12) were the main clinical signs. Lumbar puncture yielded abnormal cerebrospinal fluid in 6/6 cases. Cerebral computed tomographic scan ab
Patients with the acquired immunodeficiency syndrome (AIDS) often have hypoalbuminemia. We report the case of a patient with AIDS in whom marked hypoalbuminemia developed due to a protein-losing enteropathy caused by small intestinal Kaposi s sarcoma--an entity not previously reported in AIDS. The patient presented wi
Huang CT; McGarry T; Cooper S; Saunders R; Andavolu R
Disseminated histoplasmosis is predominantly a disease of the immunocompromised. However, it has been reported infrequently in patients with the acquired immunodeficiency syndrome (AIDS), and then almost exclusively from patients residing in endemic areas. We report five cases of disseminated histoplasmosis in patient
Psychiatric symptoms in AIDS have been noted in the literature. The case report of a young man with HIV showing psychotic features is presented. The course of the illness points to a possible schizophrenia incipiens. This raises two issues: the neurotropic potential of the virus and its involvement in the occurrence o
Since September 1984, six cases of acquired immune deficiency syndrome (AIDS) and 11 cases of AIDS related complex (ARC) have been reported in Thailand . All people with AIDS were homosexual or bisexual men; two were Thai and the rest were European or American. Nine of the 11 peop
Int Nurs Rev. 1987 May-Jun;34(3):64-6. Unique Identifier : AIDSLINE MED/87221338
Wells RJ
As a result of the AIDS epidemic the nursing profession and especially oncology nurses are facing challenges never before encountered, including the need to rethink a number of values and concepts. Nursing has a unique opportunity to prove its worth as a caring profession by successfully meeting these challenges.
Abbott and Wellcome enzyme linked immunosorbent assays (ELISAs) for detection of antibodies to human immunodeficiency virus (HIV) were compared in tests on 932 sera collected predominantly from male homosexuals attending a sexually transmitted disease (STD) clinic in central London. Two hundred and twenty three sera h
Berrebi A; Puel J; Federlin M; Gayet C; Watrigant MP; Monrozies X; Kobuch WE
We describe the gynaecological and obstetrical management of 48 HIV seropositive, pregnant women and review the literature. We did not find that pregnancy aggravated the development of the condition from the asymptomatic anti-HIV related complex (ARC) and AIDS. It seemed that fetal malformations, especially of the fac
In November 1985, St. Clare s Hospital in New York City became the first hospital on the East Coast (the second in the country) to open a separate dedicated unit for AIDS patients. Staff succeeded despite some seemingly impossible contradictions: John Cardinal O Connor of the Archdiocese of New York, who has been oppo
H-9 cells producing HIV were examined by electron microscopy to value the virus-host cell relationships. HIV fine structure was also studied. HIV induces little cellular damages and it can penetrate into the cytoplasm by phagocytosis. Phagocytosis of the virus could play an important role in the mechanism of cellular
Med Hypotheses. 1987 Apr;22(4):429-41. Unique Identifier : AIDSLINE MED/87228438
Dictor MR
To explain the epidemiology of Kaposi s sarcoma, including its predominance in men, I present a theory based on three concurrent factors: immunodeficiency, exposure to a specific viral agent, and a recessive, highly prevalent X-linked regulatory gene. The X-linked locus is inferred from comparing the aberrant lymphati
HIV is the causative agent of AIDS. It is a retrovirus of the Lentiviridae family whose known biological properties may account for the diversity of the pathology it causes. HIV displays selective tropism for CD4+ lymphocytes and for cells of the macrophage lineage, the cellular receptor involving the CD4 molecule its
Am J Epidemiol. 1987 Jul;126(1):14-24. Unique Identifier : AIDSLINE MED/87238607
Brookmeyer R; Gail MH; Polk BF
The acquired immunodeficiency syndrome (AIDS) is caused by a retrovirus, the human immunodeficiency virus (HIV). A rapid and convenient method to identify additional cofactors or risk modifiers and markers of disease progression is to study a cohort prevalent with HIV antibody. However, because the time of viral infec
Biochem Biophys Res Commun. 1987 Jun 15;145(2):884-7. Unique Identifier : AIDSLINE MED/87241607
Nguyen TD; Scheving LA
Thymosin alpha 1 has many effects on immune function and its absence in primary immunodeficiency states produce a clinical presentation similar to the one encountered in acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus (HIV), the etiologic agent of AIDS, binds to T4 helper/inducer lymphocytes t
Arico M; Azzini M; Caselli D; Maccario R; Marseglia G; Michelone G
The characteristics of acquired immunodeficiency syndrome (AIDS) in children have been described in several reports. The occurrence of specific anti-HTLV-III/LAV seropositivity in children born to seropositive mothers is also becoming more frequent in Italy . We report 15 cases of se
Lymphadenopathy is an important component of a wide variety of different illnesses including the acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related conditions. In this study two pairs of observers independently examined the lymph nodes of hemophiliacs younger than 18 years of age to dete
Schaison G; Leverger G; Gluckman E; Baruchel A; Benbunan M; Boiron M
The prevalence of AIDS now approaches 1% in patients with hemophilia and laboratory evidence of abnormal immunoregulation is found in 50% of patients with severe hemophilia. Current evidence indicates that a human retrovirus HIV/LAV is the etiologic agent which can be transmitted through the administration of blood pr
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3797-801. Unique Identifier : AIDSLINE MED/87231904
Nara PL; Robey WG; Gonda MA; Carter SG; Fischinger PJ
The presence of antibody-dependent complement-mediated cytotoxicity (ACC) was assessed in humans and chimpanzees, which are capable of infection with human immunodeficiency virus isolate HTLV-IIIb, and examined in the goat after immunization with the major viral glycoprotein (gp120) of HTLV-IIIb. In infected humans no
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3826-30. Unique Identifier : AIDSLINE MED/87231910
Pahwa R; Good RA; Pahwa S
Infection with the human immunodeficiency virus (HIV) is characteristically associated with hypergammaglobulinemia in both adult and pediatric cases. We report herein four infants who had an HIV infection in association with severe hypogammaglobulinemia and did not exhibit antibodies against HIV. HIV was isolated ante
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3876-80. Unique Identifier : AIDSLINE MED/87231920
Goudsmit J; Epstein LG; Paul DA; van der Helm HJ; Dawson GJ; Asher DM; Yanagihara R; Wolff AV; Gibbs CJ Jr; Gajdusek DC
The presence of human immunodeficiency virus (HIV) antigens in cerebrospinal fluid (CSF) was associated with progressive encephalopathy in adult and pediatric patients with acquired immunodeficiency syndrome (AIDS). HIV antigen was detected in CSF from 6 of 7 AIDS patients with progressive encephalopathy. By contrast,
LAV/HTL VIII virus found in 1983, renamed HIV in 1986, is doing with many clinical manifestations among which AIDS is only ultimate one, and the more serious aspect of infection by the virus. At each stage of the disease, oro-facial manifestations can be encountered, often the first one. That emphasises for oral medic
Buccal lesions observed in the clinical setting of human immunodeficiency virus (HIV) infection constitute a diverse group of pathological entities. Several are related to the opportunistic infections observed in association with HIV infection. Hairy leukoplakia is a recently described benign lesion that is presumably
South Med J. 1987 Jun;80(6):683-6. Unique Identifier : AIDSLINE MED/87234542
Berger JR; Moskowitz L; Fischl M; Kelley RE
Neurologic disease was the harbinger of the acquired immunodeficiency syndrome (AIDS) in 26 (20%) of 132 patients and ultimately developed in 83 (63%). The most common neurologic disorder heralding AIDS was toxoplasmic encephalitis (17 cases) followed by cryptococcal meningitis (six), retinitis (three), progressive mu
Boll Ist Sieroter Milan. 1986;65(6):557-62. Unique Identifier : AIDSLINE MED/87213692
Carluccio AV; Tiddia F; Pautasso M; Piro S; Valdes E; Maccioni A; Piu G
This work describes the first case of Acquired Immuno-Deficiency Syndrome (AIDS) to be found in Sardinia. The patient was an adult male drug-addict who died following a respiratory inadequacy due to bronchial pneumonia resulting from Pneumocystis carinii (PCP). For diagnostic purposes the emphasis is laid on the impor
Mathe G; Misset JL; Gil-Delgado M; Musset M; Reizenstein P; Canon C
Zinc is an trace metal necessary for T cell differentiation and maturation. Forty-two patients, with Aids Related Complex or malignancy in remission and with severe and stable CD4 lymphoid cells cytopenia were submitted to zinc gluconate, 125 mg twice daily orally for three weeks. Reevaluation of T cell subsets one we
McDougal JS; Maddon PJ; Dalgleish AG; Clapham PR; Littman DR; Godfrey M; Maddon DE; Chess L; Weiss RA; Axel R
Taken together, our studies suggest a mechanism of AIDS virus infection that initially involves the specific association of the AIDS virus with T4 molecules on the cell surface. This association does not require additional T-cell-specific molecules and can be demonstrated on both B lymphocytes and epithelial cell line
J Immunol. 1987 Jun 1;138(11):3731-6. Unique Identifier : AIDSLINE MED/87224009
Robert-Guroff M; Giardina PJ; Robey WG; Jennings AM; Naugle CJ; Akbar AN; Grady RW; Hilgartner MW
Sera collected in New York in 1984 from 77 patients with homozygous beta-thalassemia were assayed for antibodies to HTLV-III by ELISA and Western blot techniques. Eight (12%) of the 66 hypertransfused thalassemics were seropositive. Retrospective sera of these eight individuals were examined by radioimmune precipitati
JAMA. 1987 Jun 12;257(22):3105-7. Unique Identifier : AIDSLINE MED/87226563
Rhoads JL; Wright DC; Redfield RR; Burke DS
Twenty-four percent (7/29) of human immunodeficiency virus-infected women seen at Walter Reed Army Medical Center between 1983 and 1986 presented with a history of chronic refractory vaginal candidiasis. In addition to vaginal candidiasis, all patients were found to have oral thrus
Klin Wochenschr. 1987 Mar 16;65(6):287-8. Unique Identifier : AIDSLINE MED/87227176
Luthy R; Ledergerber B; Tauber M; Siegenthaler W
The prevalence of antibodies to the human immune deficiency virus was determined in 123 prostitutes. Of 18 intravenous drug abusers 14 were anti-HIV positive, all others, with one exception, were seronegative. Neither race, nor number of clients, nor sexual practices correlated with seropositivity.
Harms G; Laukamm-Josten U; Bienzle U; Guggenmoos-Holzmann I
A series of 320 German i.v. drug abusers (32.2% female, 67.8% male) were tested in a cross-sectional study for antibodies against HIV. Seroprevalence increased from 0 in those who discontinued i.v. drug abuse before 1982 to 37.2% in those who stopped injecting drugs in 1985/1986 or who were still addicted. Antibodies
Gramatzki M; Burmester GR; Heyder N; Nusslein HG; Rodl W; Grote W; Monner DA; Muhlradt PF; Kalden JR
To improve immune functions in an interleukin-2 ( IL-2 ) deficient hemophiliac AIDS patient suffering from severe Pneumocystis carinii pneumonia, treatment with IL-2 was started in addition to standard antimicrobial therapy. Highly purified IL-2 was administered subcutan
Minerva Med. 1987 May 15;78(9):575-86. Unique Identifier : AIDSLINE MED/87229695
Mauro L; Di Gregorio F
The epidemiology, physiopathology and clinical aspects of adult and paediatric AIDS (Acquired Immune Deficiency Syndrome) are discussed and recent bibliographical references are reported.
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3891-5. Unique Identifier : AIDSLINE MED/87231923
Chanh TC; Dreesman GR; Kennedy RC
A monoclonal anti-idiotypic (anti-Id) antibody, HF1.7, was generated against anti-Leu-3a, a mouse monoclonal antibody (mAb) specific for the CD4 molecule on human helper/inducer T lymphocytes. The anti-Id nature of HF1.7 was demonstrated by the following properties. (i) It reacted in a solid-phase immunoassay with ant
Thromb Haemost. 1987 Feb 3;57(1):41-3. Unique Identifier : AIDSLINE MED/87235172
Lopaciuk S; Kacperska E; Gloskowska-Moraczewska Z; Maslanka K; Uhrynowska M; Kraj M; Seyfried H
Sera of 520 multitransfused haemophiliacs were examined for antibody to HIV; 447 patients had haemophilia A and 73 had haemophilia B. In 382 patients with haemophilia A and in 62 with haemophilia B solely Polish-made blood products were used for replacement therapy. The remaining haemophiliacs had also received import
Raffoux C; David V; Couderc LD; Rabian C; Clauvel JP; Seligmann M; Colombani J
HLA-A, B, DR phenotype frequencies were studied in 69 homosexual patients with persistent generalized lymphadenopathy (PGL), in 8 patients with LAV/HTLV III related thrombocytopenic purpura and in 21 homosexual controls. Antigen DR5 was significantly increased in PGL patient groups as compared to controls. Our finding
A generalized lymphadenopathy syndrome (GLS) occurs in persons at high risk for development of acquired immunodeficiency syndrome (AIDS). The natural history and immunologic status of patients with GLS are not fully known, although in some persons GLS may progress to full AIDS. We present the clinical and immunologic
The acquired immune deficiency syndrome (AIDS) is a novel epidemic form of immunodeficiency that has been widely recognized within the last six years. AIDS is characterized by Kaposi s sarcoma, B cell lymphoma, and/or life-threatening opportunistic infections superimposed on an immune deficiency state which consists o
Serial T-cell subsets and platelet counts were determined in a cohort of 84 hemophiliacs in whom time of seroconversion for human immunodeficiency virus (HIV) antibody could be ascertained. An abrupt decrease in the number of T-helper (T4) cells was seen in 9 patients 12 to 24 months before the acquired immunodeficien
Ann Intern Med. 1987 Jul;107(1):7-13. Unique Identifier : AIDSLINE MED/87239754
Suffredini AF; Ognibene FP; Lack EE; Simmons JT; Brenner M; Gill VJ; Lane HC; Fauci AS; Parrillo JE; Masur H; et al
During a 4.4-year period, nonspecific interstitial pneumonitis was seen in 41 of 110 (38%) patients with the acquired immunodeficiency syndrome and accounted for 32% (48/152) of all episodes of clinical pneumonitis. Diffuse alveolar damage was typically a feature of nonspecific interstitial pneumonitis, but neither lu
Biochem Biophys Res Commun. 1987 May 29;145(1):269-76. Unique Identifier : AIDSLINE MED/87241510
Balzarini J; Pauwels R; Baba M; Robins MJ; Zou RM; Herdewijn P; De Clercq E
The 2 ,3 -dideoxyriboside of 2,6-diaminopurine(ddDAPR) is, like 2 ,3 -dideoxyadenosine (ddAdo), a potent and selective inhibitor of human immunodeficiency virus (HIV) in vitro. The ddDAPR compound inhibits HIV antigen expression and HIV-induced cytopathogenicity in MT4 cells at a 50% effective dose (ED50) of 2.5-3.6 m
Biochem Biophys Res Commun. 1987 May 29;145(1):277-83. Unique Identifier : AIDSLINE MED/87241511
Balzarini J; Robins MJ; Zou RM; Herdewijn P; De Clercq E
The 2 ,3 -dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2 ,3 -didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2 -deoxyadenosine (dAdo), bu
Lymphocytes in the periphery of the normal human cornea are identified as being only T lymphocytes by immunohistochemical methods. OKT-4 positive cells (T-helper/inducer lymphocytes) and OKT-8 positive cells (T-suppressor/cytotoxic lymphocytes) are found in similar numbers in most of the corneas examined. OKT-4 positi
The Acquired Immune Deficiency Syndrome is one of the most challenging problems of medical sciences in the last decade, because it is a completely new disease, which appears to be inevitably fatal. Although much effort has been put in the development of therapeutic and prophylactic methods ever since the recognition o
Remarkable progress has been made in antiviral chemotherapy. Six approved antiviral drugs are now available for the treatment of various viral infections. Trifluridine, idoxuridine and vidarabine are all effective in patients with herpes keratitis; trifluridine is preferred due to its low toxicity.
Van de Perre P; Clumeck N; Steens M; Zissis G; Carael M; Lagasse R; De Wit S; Lafontaine T; De Mol P; Butzler JP
A seroepidemiological study was performed on HTLV-III, T. pallidum, C. trachomatis and Hepatitis B virus (HBV), in Butare, Rwanda , among 33 female prostitutes, 25 male customers of prostitutes, and 60 male and female controls. As compared with female controls the prostitutes had a
Int J Immunopharmacol. 1987;9(2):165-73. Unique Identifier : AIDSLINE MED/87221086
Handzel ZT; Berner Y; Segal O; Burstein Y; Buchner V; Pecht M; Levin S; Burstein R; Milchan R; Bentwich Z; et al
The feasibility of using Thymic Humoral Factor (THF) for immunomodulation in asymptomatic male homosexuals was evaluated in a study on fifteen subjects with T-cell impairments, selected on the basis of a 2SD reduction in T helper/inducer (T4+) cells and one additional lymphocytic defect. Following two biweekly courses
In a multicenter cooperative study, an enzyme immunoassay (EIA) using purified antigen of lymphadenopathy-associated virus was compared with radioimmune precipitation (RIP) for detection of antibody to human immunodeficiency virus (HIV) in 634 patients with acquired immunodeficiency syndrome or related conditions, 687
The distribution and concentration of human T (tryptase-positive, chymase-negative) and TC (tryptase-positive, chymase-positive) mast cells were examined in Carnoy s-fixed specimens of the gastrointestinal tract of normal individuals, patients with inflammatory bowel diseases, and patients with immunodeficiency disord
Ivo dos Santos J; Galvao-Castro B; Mello DC; Pereira HG; Pereira MS
A dot enzyme immunoassay for antibody to HIV has been developed and tested with a panel of positive and negative sera. It has proved to be of equal or greater sensitivity compared with a commercial ELISA kit, is simple and quick to perform, requires neither sophisticated equipment nor highly trained technical staff. T
Toxoplasma gondii, the causative agent of toxoplasmosis, is one of the commonest protozoan parasites of man. It is found world-wide. Although the infection is common as indicated by a high prevalence of toxoplasma antibody among almost all human populations, the clinical disease is observed in only a small proportion
Monoclonal antibodies were raised against the gag proteins of a British isolate of the human immunodeficiency virus (HIV), CBL-1. Seven of the monoclonal antibodies recognized HIV gag-coded proteins of 55,000 mol. wt. (p55) and 24,000 mol. wt. (p24), three recognized p55/p18 and three p18 alone. Cross-competition assa
Kern P; Meigel W; Racz P; Gottesleben A; Dettke T; Dietrich M
Twenty-three patients with biopsy-proven Kaposi s sarcoma and HIV infection were treated with recombinant interferon-alpha-2a (Roferon-A). Two dosage regimens were used: 21 patients received 18 X 10(6) units intramuscularly per day for 3 months, followed by injections of 18 X 10(6) units three times a week. The remain
The clinical development of the recombinant alpha interferons has provided a prototype for the clinical development of biological compounds. With over 5,000 patients now treated with these compounds, some general principles have emerged that have wider implications for phase I-II strategies for testing other biologica
Anti-HIV seroconversion was recorded in a patient by means of Western blot, immunofluorescence and ELISA analysis on sera taken at one to five day intervals. Seroconversion was first detected in the Western blot by antibodies to p15 and p24 and was followed by a rapid increase in levels of antibodies during the follow
Piris MA; Rivas C; Morente M; Rubio C; Martin C; Olivia H
An immunohistochemical and ultrastructural study of 14 cases of persistent and generalized lymphadenopathy (PGL), acquired immune deficiency syndrome (AIDS) related, revealed florid follicular hyperplasia, follicular dendritic cell (FDC) lysis, lymphoid follicle invaginations, increased presence of T8 cells in germina
Cryptococcus neoformans fungemia occurred in a patient with the acquired immunodeficiency syndrome (AIDS). The BACTEC 460 radiometer failed to detect Cryptococcus neoformans in eight aerobic BACTEC 6B culture bottles inoculated with the patient s blood. The diagnosis of cryptococcemia was established by terminal (seve
Am J Ophthalmol. 1987 Jun 15;103(6):798-801. Unique Identifier : AIDSLINE MED/87238801
Pepose JS; MacRae S; Quinn TC; Ward JW
Four corneas from two cadavers that later had positive test results on enzyme-linked immunosorbent assays and Western blot analysis for antibodies against the human immunodeficiency virus were inadvertently transplanted to recipients who were without known risk of human immunodeficiency virus infection. We performed s
Ann Intern Med. 1987 Jul;107(1):78-87. Unique Identifier : AIDSLINE MED/87239756
Berger JR; Kaszovitz B; Post MJ; Dickinson G
Progressive multifocal leukoencephalopathy, a common complication of infections with human immunodeficiency virus (HIV), occurs in as many as 3.8% of patients with the acquired immunodeficiency syndrome (AIDS). We report 16 cases and review 12 previously reported cases of progressive multifocal leukoencephalopathy ass
Ann Neurol. 1987 May;21(5):490-6. Unique Identifier : AIDSLINE MED/87240105
Pumarola-Sune T; Navia BA; Cordon-Cardo C; Cho ES; Price RW
Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal
Hay CR; Preston FE; Triger DR; Greaves M; Underwood JC; Westlake L
In an attempt to predict progressive liver damage in hemophiliac patients by noninvasive means, we conducted a retrospective analysis of clinical and laboratory data from 44 liver biopsies taken from 35 hemophiliac patients. This showed that serum IgG was normal in patients with chronic persistent hepatitis (CPH) but
CD4 functions as the cell-surface receptor for human immunodeficiency virus (HIV); however, the mechanism of virus entry into susceptible cells is unknown. To explore this question we used a human T lymphoblastic cell line (VB) expressing high levels of surface CD4. Neutralization of endosomal compartments (pH greater
In a prospective study of cryoprecipitate administration to patients who had never received large pool concentrates, no evidence of hepatitis or HIV infection was detected in a follow up period of one year. Following the introduction of screening of blood donors for anti-HIV in the UK in October 1985 the use of cryopr
Although antigen-nonspecific suppressor factors described by various investigators appear to exhibit a certain amount of heterogeneity in both physical and biological properties, these proteins also exhibit significant similarities. Nonspecific suppressor factors are generally produced by Ly 2+ (murine) or OKT8+ (huma
Six mouse hybridomas secreting monoclonal antibodies specific for the glycoproteins of human immunodeficiency virus were developed. All six antibodies reacted by radioimmunoprecipitation with the glycoprotein precursor of 150,000 daltons as well as one of the proteolytic processing products of 110,000 daltons (gp110)
We studied the effect of human immunodeficiency virus (HIV) infection on the surface-marker expression of the human promonocytic cell line U937. U937 cells persistently produced HIV as detected by reverse transcriptase activity in culture supernatant. Expression of HLA class II antigens on U937/HIV cells was decreased
The effects of heat treatment of serum samples on the hormone analyses used in this laboratory were studied. Total T4, testosterone, progesterone, and growth hormone were not systematically affected by heat treatment over the whole range of analyte concentrations studied; for thyroid stimulating hormone, no effect was
J Immunol. 1987 Jun 1;138(11):3725-30. Unique Identifier : AIDSLINE MED/87224008
Giorgi JV; Fahey JL; Smith DC; Hultin LE; Cheng HL; Mitsuyasu RT; Detels R
Low circulating CD4 cell numbers and CD4 cell dysfunction are distinguishing features of HIV-mediated disease. The current study delineates the in vivo effects of HIV on distinct functional subsets of CD4 cells in homosexually active men who have been infected with HIV for different lengths of time, and examines the c
Thirty-five homosexual men who had been the regular sexual partners (for at least 6 months) of anti-HIV-positive patients with AIDS (N = 18) or PGL (N = 17) were studied. Twenty-one (60%) were seropositive, but 14 (40%) were consistently anti-HIV-negative. The duration of relationship with the index case was not stati
19 (51%) of 37 hemophiliac children and adolescents regularly treated with factor VIII and IX concentrates were positive for HTLV III antibodies. The prevalence of HTLV III antibodies was higher in patients with severe hemophilia (64%) requiring frequent administration of concentrates than in patients with mild hemoph
Analysis of the responses of 1,247 health care providers to questionnaires immediately before and after educational programs on acquired immunodeficiency syndrome (AIDS) revealed significant (P less than .05) improvements in accuracy of knowledge about 7 of 15 modes of transmission and 7 of 11 means of infection contr
Thromb Res. 1987 Mar 1;45(5):625-34. Unique Identifier : AIDSLINE MED/87235204
Skjonsberg OH; Gravem K; Kierulf P; Godal HC
In order to evaluate the influence of heat treatment (68 degrees C for 24 or 72 hours) on the essential components of antihaemophilic cryoprecipitate, i.e. factor VIII coagulant activity (VIII:C), von Willebrand factor (VIIIR:Ag and VIIIR:RCF) and fibrinogen, ordinary lyophilized cryoprecipitate was compared to heat t
Twenty four patients with angio-immunoblastic lymphadenopathy (AILD) presenting between 1974 and 1985 have been reviewed. Clinical features at presentation included rash, fever, lymphadenopathy and hepatosplenomegaly in 75% of patients. Polyclonal hypergammaglobulinaemia was seen in 19/20 patients; 5 had normal immuno
The expression of phenotypic markers on B lymphocytes in patients with the acquired immune deficiency syndrome (AIDS), in human immunodeficiency virus (HIV) seropositive individuals, and in healthy seronegative donors was examined by two-color flow cytometry. Patients with AIDS and HIV-seropositive individuals showed
Much effort has been devoted to the analysis of antibodies to acquired immunodeficiency syndrome virus antigens, but no studies, to our knowledge, have defined antigenic sites of this virus that elicit T-cell immunity, even though such immunity is important in protection against many other viruses. T cells tend to rec
Eight patients with acquired immune deficiency syndrome (AIDS) presented complications affecting the nervous system. The complaints were headache, seizure, confusion or hallucination. Neurologic manifestations included meningitis, focal deficits, cranial nerve palsy, and dementia .
South Med J. 1987 Jun;80(6):687-91, 697. Unique Identifier : AIDSLINE MED/87234543
Pifer LL; Wang YF; Chiang TM; Ahokas R; Woods DR; Joyner RE
Results of our study suggest that white Southern male homosexuals without clinical evidence of AIDS who patronize gay bars may have significant zinc deficiency and moderately depressed T-helper/T-suppressor cell ratios. No single causative factor could be identified to explain the significantly low zinc and elevated c
Cancer Res. 1987 Jun 15;47(12):3190-4. Unique Identifier : AIDSLINE MED/87215619
Tavares L; Roneker C; Johnston K; Lehrman SN; de Noronha F
Due to similarities between human immunodeficiency virus and feline leukemia virus, the etiological agents of acquired immunodeficiency syndromes in humans and cats, the feline system was used as a model to conduct preliminary investigations as to the efficacy of the thymidine analogue 3 -azido-3 -deoxythymidine (
Doc Ophthalmol. 1986 Dec 30;64(1):77-85. Unique Identifier : AIDSLINE MED/87217984
Visser OH; Bos PJ
The number of AIDS patients is still increasing. In 30-50% of these patients ocular lesions occur, which are of diagnostic and prognostic significance. If the life-span of AIDS patients lengthens in the future, adequate treatment of the ocular conditions will become increasingly important. The two most important ocula
EMBO J. 1987 Feb;6(2):389-95. Unique Identifier : AIDSLINE MED/87218493
Ohtani K; Nakamura M; Saito S; Noda T; Ito Y; Sugamura K; Hinuma Y
Human T-cell leukemia virus type I has a unique sequence, pX, between env and the 3 long terminal repeat (LTR). One of its products, p40, activates gene expression directed by the LTR in a trans-acting manner. We have analysed the mechanism of this trans-activation mediated by p40 in human T cells co-transfected with
Three patients with biopsy diagnosed invasive cytomegalovirus infection of the colon have been seen in the context of the acquired immune deficiency syndrome (AIDS). Cytomegalovirus colitis presented with fever, abdominal distention, bloody diarrhoea and weight loss. Plain abdomina
Immunol Lett. 1987 Jan;14(2):139-42. Unique Identifier : AIDSLINE MED/87220619
Zav'yalov VP; Denesyuk AI
Within the 3 end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre
Antigenic cross-reactivity of the human acquired immunodeficiency disease syndrome virus LAV/HTLV-III with the lentiviruses visna virus, caprine arthritis encephalitis virus (CAEV), and equine infectious anemia virus (EIAV) was determined with indirect enzyme-linked immunosorbent assays, immunoblot analysis, and virus
Tobler A; Gasson J; Reichel H; Norman AW; Koeffler HP
We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). The regulation of GM-CSF expressi
De Santo NG; Tarro G; Giordano C; Capodicasa G; Esposito C; Flaminio G; Sodano G; Caropreso MR; Pluvio M; Giordano D; et al
A group of 484 patients having regular haemodialysis was tested for the presence of antibodies to the human immunodeficiency virus (HIV). With a commercial enzyme-linked immunoassay kit, the serum of 17 appeared positive. When these 17 samples were retested by a different method, however, none was found to contain ant
Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP-BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The exten
Elovaara I; Iivanainen M; Valle SL; Suni J; Tervo T; Lahdevirta J
CSF protein and cellular profiles were studied in 28 HIV-infected patients. Twenty of them had neurological complaints, but only 6 patients had objective neurological deficits such as dementia , ocular motility disorders or polyneuropathy. The serum/CSF HIV antibody ratio was on ave
J Med Primatol. 1987;16(2):131-8. Unique Identifier : AIDSLINE MED/87226107
Broderson JR
The safety recommendations for studies on acquired immunodeficiency syndrome (AIDS) using nonhuman primates are based on knowledge about the epidemiology of the disease in humans, characteristics of the virus, and standard methods for handling nonhuman primates in the laboratory. Appropriate procedures avoid exposure
Distinct transcriptional regulatory sequences located within the upstream sequences required for p40x trans-activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) were chemically synthesized and cloned upstream of the basal HTLV-I LTR promoter. Plasmids containing a single 21-base-pai
JAMA. 1987 Jun 12;257(22):3082-7. Unique Identifier : AIDSLINE MED/87226559
Erice A; Jordan MC; Chace BA; Fletcher C; Chinnock BJ; Balfour HH Jr
Thirty-one immunocompromised patients with severe cytomegalovirus ( CMV ) disease were treated with intravenous ganciclovir. Twenty-one patients had received transplants--15 bone marrow recipients, five renal allograft recipien
Klin Wochenschr. 1987 Mar 16;65(6):259-63. Unique Identifier : AIDSLINE MED/87227172
Weber T; Buttner W; Felgenhauer K
A case of acquired immune deficiency syndrome (AIDS) and a case of AIDS-related complex (ARC) are described. In both instances comparative Western blot analysis of cerebrospinal fluid (CSF) and serum samples show evidence of qualitative differences in antibody-binding patterns to viral polypeptides.
Med Hypotheses. 1987 Apr;22(4):373-86. Unique Identifier : AIDSLINE MED/87228433
Whittingham S; McNeilage LJ; Mackay IR
It is proposed that the initiating event in primary Sjogren s syndrome is infection with Epstein-Barr virus (EBV), and that the autoimmune exocrinopathy that progresses to keratoconjunctivitis sicca and xerostomia is a sequel to this. Our hypothesis is based on the findings that the antinuclear antibody, anti-La(SS-B)
Pepose JS; Newman C; Bach MC; Quinn TC; Ambinder RF; Holland GN; Hodstrom PS; Frey HM; Foos RY
Ganciclovir is a new antiviral compound (also called BW B759U, DHPG, BIOLF-62, and 2 NDG) that has been used for the treatment of cytomegalovirus ( CMV ) retinopathy in immunocompromised patients (bone marrow recipients or acqu
A 15-month prospective study of 109 patients with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) was conducted. Cytomegalovirus ( CMV ) retinitis developed in 18 of these patients; they were treated with ganciclovir. Five other patien
Rogers MF; Thomas PA; Starcher ET; Noa MC; Bush TJ; Jaffe HW
Since national surveillance for acquired immunodeficiency syndrome (AIDS) began in 1981, the Centers for Disease Control (CDC) has received reports of more than 20,000 cases of AIDS in the United States . As of December 31, 1985, 307 of these cases had been diagnosed in children younger
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3653-7. Unique Identifier : AIDSLINE MED/87231876
Inoue J; Yoshida M; Seiki M
The pX sequence of human T-cell leukemia virus type I codes for three products: p40x, p27x-III, and p21x-III. p40x is a transcriptional trans-activator that activates not only the viral long terminal repeat but also cellular genes for interleukin 2 and its receptor. p27x-III and p21x-III are not required for transcrip
Science. 1987 Jun 5;236(4806):1315-8. Unique Identifier : AIDSLINE MED/87234338
Giese NA; Robbins KC; Aaronson SA
The v-sis oncogene encodes a platelet-derived growth factor (PDGF)-related product whose transforming activity is mediated by its functional interaction with the PDGF receptor. PDGF, as well as processed forms of the v-sis gene product, is a disulfide-linked dimer with eight conserved cysteine residues in the minimum
The nucleotide sequence of the integrated form of the genome of the equine infectious anemia virus was determined. By comparison with LTR sequences of other retroviruses, signals for the control of viral gene transcription and translation could be identified in the EIAV LTR. Open reading frames for gag and pol genes w
Rapid detection of cytomegalovirus ( CMV ) from pulmonary specimens in immunosuppressed persons may provide an origin for pneumonia. In situ DNA hybridization has been effective for detection of CMV in otherwise nondiagnostic h
A case of Pneumocystis carinii involvement of the bone marrow in acquired immunodeficiency syndrome is reported. The literature is reviewed for other cases of known extrapulmonary dissemination of Pneumocystis. Potential mechanisms of dissemination of Pneumocystis and its clinical implications are discussed.
Srinivasan A; York D; Ranganathan P; Ferguson R; Butler D Jr; Feorino P; Kalyanaraman V; Jaffe H; Curran J; Anand R
The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral gen
This hypothesis is a presentation of a unifying model of the interferon (IFN) system as a cascade of sequentially interacting responses of IFNs-alpha, -beta, and -gamma involved in modulation of the immune response. We propose that every antigen is an IFNogen. The first stage(s) of immune responsiveness is associated
Lishner M; Pomeranz A; Rozenbaum E; Korzets Z; Shenkman L
A 14-year-old patient presented with hypercalcaemia-induced acute renal failure. Investigation yielded a diagnosis of T-cell leukaemia. Chemotherapy resulted in complete remission, a return of serum calcium levels to normal and consequent improvement of renal function.
Ando Y; Nakano S; Saito K; Shimamoto I; Ichijo M; Toyama T; Hinuma Y
HTLV-I is commonly believed to be transmitted from HTLV-I seropositive mothers to infants via breast milk. In 11 of 24 breast-fed infants born to HTLV-I seropositive mothers, HTLV-I antigen-positive cells were detected in peripheral blood samples obtained 12 months after birth. In sharp contrast, they were detected in
Human immunodeficiency virus (HIV), the etiologic agent of acquired immunodeficiency syndrome (AIDS), was rapidly cytopathic to SKT-1B, a cell line established from a patient with adult T cell leukemia, in vitro. This cytopathic effect was preceded by the expression of HIV antigen, defined with a monoclonal antibody (
Biological interleukin-2 ( IL-2 ) assays require cells that proliferate only in the presence of IL-2. The most often used human cells for this purpose have been phytohaemagglutinin (PHA)-stimulated buffy coat lymphocytes made dependent on IL-2. The results obtained by th
Nakao Y; Koizumi T; Matsui T; Matsuda S; Nakagawa T; Katakami Y; Fujita T; Maeda S; Morikawa S; Ito Y
The effects of 1 alpha, 25-dihydroxyvitamin D3 [1,25-(OH)2D3] on proliferation and de novo DNA synthesis were studied in the following established human leukemia cell lines: lymphoblastic T-cell lines HPB-ALL, CCRF-HSB-2, p12/lchikawa, and HPB-MLT; adult T-cell leukemia- (ATL) and human lymphotropic virus type I (HTLV
Lancet. 1987 May 30;1(8544):1249-53. Unique Identifier : AIDSLINE MED/87227675
Gaines H; von Sydow M; Sonnerborg A; Albert J; Czajkowski J; Pehrson PO; Chiodi F; Moberg L; Fenyo EM; Asjo B; et al
The antibody response in 20 homosexual men with symptomatic primary HIV infection was studied with ten different antibody assays (enzyme-linked immunosorbent assays, indirect immunofluorescence assays, radioimmunoprecipitation [RIPA], and western blot). HIV antibodies were detectable by all the assays within 2 months
Lancet. 1987 Jun 6;1(8545):1286-92. Unique Identifier : AIDSLINE MED/87227710
Carter WA; Strayer DR; Brodsky I; Lewin M; Pellegrino MG; Einck L; Henriques HF; Simon GL; Parenti DM; Scheib RG; et al
10 patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), or lymphadenopathy syndrome (LAS) were given 200-250 mg ampligen, a mismatched double-stranded (ds) RNA with in-vitro antiviral activity against human immunodeficiency virus (HIV), twice a week for up to 18 weeks, without side-
Human T-cell lymphotropic virus type III B (HTLV-III B) derived from H9/HTLV-III cells was cloned by a plaque-forming assay. Cloned viruses showed different restriction cleavage patterns, suggesting that HTLV-III B is a mixture of several viruses. Using two different neutralization assay systems, we compared the envel
Epstein L; Blumberg B; Crowley J; Samuel K; Goudsmit J; Cook S; Dowling P
Serum HTLV-I antibodies were measured in 17 MS patients and 2 closely matched control groups by 2 different independent assays. A highly sensitive particle agglutination test was used to detect HTLV-I core protein antigens and an immunoblot assay with E. coli-expressed P21E transmembrane protein was employed to detect
One hundred twenty-eight serum samples, collected from infants transfused at the neonatal care unit of Kyushu University Hospital, Fukuoka, Japan , were tested for the presence of antibody to human T-cell lymphotropic virus type I (HTLV-I) by the enzyme-linked immunosorbent assay and
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1763-71. Unique Identifier : AIDSLINE MED/87240287
Takatsuki K
ATL is a unique T-cell malignancy first described by Takatsuki and colleagues in 1970s. We estimate that more than 300 patients a year have been detected in the endemic areas of Kyushu, Japan . The surface phenotype of ATL cells characterized by monoclonal antibodies is T3+, T4+, T8-
In: Mobilizing Against AIDS: The Unfinished Story of a Virus. Cambridge, Mass.: Harvard University Press, 1986 :132-146. Unique Identifier : AIDSLINE KIE/23177
This information is designed to support, not replace, the relationship that exists between you and your doctor.